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Reed Jobs launched Yosemite in August 2023 as a standalone investment firm focused on cancer research and companies developing oncology-related products. Its debut fund had an announced first close of more than $200 million. Yosemite combines research grantmaking with venture investing; the headline amount is fundraising, not evidence that a cancer treatment works.
What is Yosemite?
Yosemite grew out of Emerson Collective Health, where Jobs had led health work, and spun off as an independent firm. Its launch announcement described an oncology-focused approach that pairs grants for emerging research with venture investment in therapeutics, diagnostics and digital health. The firm said it would also provide flexible funding for incubation and early translation of research toward practical development. Yosemite’s launch announcement described the first close as oversubscribed and above $200 million.
The idea is to support work at different stages: grantmaking can help early research advance, while venture capital can support company formation and development. Those are distinct forms of financing, and neither, by itself, establishes clinical benefit or regulatory approval.
How the two fund announcements differ
The $200 million figure in the 2023 launch story refers to the first close of Yosemite’s debut fund. A later fundraising report concerns a separate, second fund.
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| Fundraising event | Amount and status | Source and date |
|---|---|---|
| Debut fund | More than $200 million at an oversubscribed first close | Yosemite, August 1, 2023 |
| Second fund | More than $200 million raised toward a $350 million target | Forbes, January 29, 2026; a dated report, not an independently audited statement |
Forbes named Amgen, Memorial Sloan Kettering Cancer Center, MIT and John Doerr among backers of the second fund. The reported amount raised should not be confused with the $350 million target.
What does Yosemite invest in?
Yosemite’s stated focus is the oncology ecosystem, rather than health care broadly. In a July 2026 interview, TechCrunch described the firm as oncology-only and reported that it builds companies from academic research as well as investing in existing ventures. Jobs said about one-third of the second fund would go to companies Yosemite creates itself or builds with academics. TechCrunch’s July 2026 interview provides that strategy detail.
This model can connect academic discoveries with company-building and commercial development. It does not mean that every funded project becomes a company, reaches clinical testing or produces an effective treatment. No comprehensive, independently verified current portfolio or company-by-company clinical status is established in the cited reports.
What does Reed Jobs say the mission is?
Yosemite’s launch announcement framed its mission as making cancer nonlethal in our lifetime. Speaking at TechCrunch Disrupt on September 19, 2023, Jobs said: “All I really care about in this world is making a huge difference for cancer patients and what we do at Yosemite, and what I’ve wanted to do my entire life, is to make cancer nonlethal in our lifetimes.” TechCrunch’s interview reports the remarks. That is an ambition, not a claim that cancer has become nonlethal or that Yosemite-backed work has demonstrated clinical efficacy.
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Why is it called Yosemite?
TechCrunch reported that the firm is named for the national park where Jobs’s parents married. The interview also covered the firm’s launch and Jobs’s stated motivation.
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