Jupiter Endovascular announced $21 million in financing on August 15, 2024, as it emerged from stealth mode. The company said the money would fund an upcoming pivotal trial of its pulmonary embolism (PE) device and development of additional uses for its catheter technology. That planned trial, SPIRARE II, has since completed enrollment, and Jupiter reported positive results in May 2026. The Vertex Pulmonary Embolectomy System remains investigational, according to the company.
What did Jupiter Endovascular announce in 2024?
On August 15, 2024, Jupiter Endovascular said it had raised $21 million in new financing and was emerging from stealth. The company identified Sonder Capital as a key participant and said multiple strategic investors also took part. It named Carl J. St. Bernard as CEO in the announcement. Jupiter Endovascular’s announcement
Jupiter said it planned to use the proceeds to support a pivotal clinical trial for PE and develop additional clinical applications of its technology, then called Endoportal Control. The financing was company funding for product development and clinical work, not a statement that the device had received regulatory approval.
What happened after the $21 million financing?
The financing was followed by additional company-reported milestones. In October 2025, Jupiter announced an oversubscribed Series B that surpassed its $40 million target. The company said the proceeds would support completion of SPIRARE II, commercialization preparation, and development of other applications of its platform. Jupiter Endovascular’s Series B announcement
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In February 2026, the company said SPIRARE II had completed enrollment. Jupiter described the study as a prospective, single-arm, multicenter pivotal trial with 123 participants. That February announcement reported 23 sites across Europe and the United States; a later May 2026 results release reported 19 sites for the same 123 participants. The releases do not explain the differing site counts. Jupiter Endovascular’s enrollment announcement
What are Endoportal Control, TFX and the Vertex system?
Jupiter initially called its technology Endoportal Control; later releases use the term Transforming Fixation, or TFX. Company materials describe a catheter that can navigate through blood vessels and then stabilize at a treatment site. The intended design is to provide added support and control during an endovascular procedure; those descriptions are design goals, not independent proof of a clinical advantage. Jupiter Endovascular’s technology description
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The Vertex Pulmonary Embolectomy System is Jupiter’s application of this technology for PE. It is the system studied in SPIRARE II, rather than a product shown by the financing announcement to be commercially available.
What did Jupiter report from the SPIRARE II trial?
In May 2026, Jupiter reported that SPIRARE II met both primary endpoints. The prospective, single-arm study enrolled 123 people with acute, intermediate-risk PE at 19 sites in the United States and Europe, according to that results release. Because the study had no comparison group, the reported results do not establish how the system performs relative to other PE treatments. The figures below are sponsor-reported, not independently verified in the sources cited here. Jupiter Endovascular’s SPIRARE II results release
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- 【Improve finger dexterity】 This product is for demonstration use only and can be used to practice basic skills in cutting, stitching, and disassembly. Improve your suture skills on various wounds and easily become an experienced doctor
- 【High quality material】 Our material is closer to real blood vessels, providing practitioners with a more realistic operating experience. Different sizes mimic a variety of vascular structures, simulating more scenarios and giving you more confidence to participate in real operations.
- 【Nursing training educational supplies】 Vascular anastomosis suture practice model has been widely used as a teaching aid for teaching, demonstration and practice, which is a thoughtful and practical gift for medical students and surgeons.
- 【Customizable teaching aids】 If you have special teaching, practice needs, please contact us.
| Reported measure | Jupiter’s May 2026 report |
|---|---|
| Mean RV/LV ratio reduction at 48 hours | 0.39 (95% confidence interval 0.33–0.45) |
| Major adverse event rate | 2.4% (3 of 123 participants; p<0.0001) |
| Technical success | 100% |
| Adjunctive thrombolytic use | None reported |
| Mean procedure time | 40.2 minutes (±16.4 minutes) |
Jupiter also reported results from SPIRARE I in October 2025: a prospective, single-arm, multicenter first-in-human study of 10 participants at two European sites. The company reported no major adverse events within 48 hours, a 32% improvement in mean pulmonary artery pressure, and a 29% improvement in mean RV/LV ratio at 48 hours. These early sponsor-reported findings come from a small study and are not a basis for broad efficacy conclusions. Jupiter Endovascular’s SPIRARE I report
In the SPIRARE II results release, Sameh Sayfo, MD, described PE as a cardiovascular disease in which restoring hemodynamic stability is important to recovery. Investigator Catalin Toma, MD, attributed the results to stable, controlled access to vessel obstructions. These are comments in the company’s release; Toma’s interpretation is not an independent comparative finding.
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Is the Vertex PE system approved or available?
Jupiter says the Vertex Pulmonary Embolectomy System is investigational and is not approved for commercial use in the United States or Europe. The company separately says its Vertex Catheter is FDA 510(k)-cleared for insertion of endovascular devices. That stated clearance applies to the catheter for that purpose; it is not approval of the Vertex Pulmonary Embolectomy System for treating PE. Jupiter Endovascular’s regulatory-status statement
What the financing and trial updates mean
The $21 million announcement was a clinical-development financing milestone, not a product launch. Jupiter later reported a larger Series B financing, completion of SPIRARE II enrollment, and sponsor-reported trial results. Those developments are separate from regulatory status: the company continues to describe its PE embolectomy system as investigational.
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